The structure, regulation, and function of human matrix metalloproteinase-13

Crit Rev Biochem Mol Biol. 2002;37(3):149-66. doi: 10.1080/10409230290771483.


Matrix metalloproteinase-13 (MMP-13) is a proteolytic enzyme that belongs to a large family of extracellular matrix-degrading endopeptidases that are characterized by a zinc-binding motif at their catalytic sites. MMP-13 has a key role in the MMP activation cascade and appears to be critical in bone metabolism and homeostasis. It also has an important role in tumor invasion and metastasis. This commentary provides a detailed overview of the regulatory mechanisms, structure, and function of human MMP-13 and highlights the key factors involved in the biology of this important molecule.

Publication types

  • Review

MeSH terms

  • Collagenases / chemistry*
  • Collagenases / genetics
  • Collagenases / metabolism*
  • Cytokines / physiology
  • Enzyme Activation
  • Gene Expression Regulation, Enzymologic*
  • Gene Expression Regulation, Neoplastic
  • Humans
  • Matrix Metalloproteinase 13
  • Neoplasms / enzymology
  • Neoplasms / genetics
  • Protein Structure, Tertiary
  • Substrate Specificity


  • Cytokines
  • Collagenases
  • MMP13 protein, human
  • Matrix Metalloproteinase 13