The hair cell's transduction channel

Curr Opin Neurobiol. 2002 Aug;12(4):380-6. doi: 10.1016/s0959-4388(02)00344-6.


The elusive transduction channel is the key player in mechanical transduction by the sensory hair cells of the inner ear. Multiple factors have thwarted molecular identification of this channel, including the lack of a definitive pharmacological signature, the paucity of hair cells, and the uniqueness of their transduction mechanism. At present, we are forced to speculate as to the transduction channel's identity; functional characteristics suggest, however, that it may well belong to transient receptor potential superfamily of ion channels.

Publication types

  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Ear* / physiology
  • Hair Cells, Auditory / anatomy & histology
  • Hair Cells, Auditory / metabolism*
  • Humans
  • Ion Channels
  • Signal Transduction*


  • Ion Channels