Yeast go the whole HOG for the hyperosmotic response

Trends Genet. 2002 Aug;18(8):405-12. doi: 10.1016/s0168-9525(02)02723-3.


An evolutionarily conserved mitogen-activated protein kinase pathway--the high osmolarity glycerol (HOG) pathway--mediates the hyperosmotic response in Saccharomyces cerevisiae. A variety of powerful approaches has generated a comprehensive picture of how cells respond to this stress condition. Several presumptive osmosensors on the cell surface recruit and activate downstream signaling components, which regulate the activity of transcription factors to control gene expression.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Cell Compartmentation / physiology
  • Fungal Proteins / metabolism
  • Gene Expression Regulation, Fungal / physiology
  • Glycerol / metabolism
  • Intracellular Signaling Peptides and Proteins
  • MAP Kinase Signaling System / genetics
  • MAP Kinase Signaling System / physiology
  • Membrane Proteins / metabolism
  • Mitogen-Activated Protein Kinase Kinases / genetics
  • Mitogen-Activated Protein Kinase Kinases / metabolism*
  • Mitogen-Activated Protein Kinases / genetics
  • Mitogen-Activated Protein Kinases / metabolism*
  • Osmotic Pressure
  • Protein Kinases*
  • Saccharomyces cerevisiae / metabolism*
  • Saccharomyces cerevisiae Proteins / genetics
  • Saccharomyces cerevisiae Proteins / metabolism*


  • Fungal Proteins
  • Intracellular Signaling Peptides and Proteins
  • Membrane Proteins
  • SHO1 protein, S cerevisiae
  • Saccharomyces cerevisiae Proteins
  • Protein Kinases
  • HOG1 protein, S cerevisiae
  • Mitogen-Activated Protein Kinases
  • Mitogen-Activated Protein Kinase Kinases
  • PBS2 protein, S cerevisiae
  • SLN1 protein, S cerevisiae
  • Glycerol