The NorR protein of Escherichia coli activates expression of the flavorubredoxin gene norV in response to reactive nitrogen species

J Bacteriol. 2002 Aug;184(16):4640-3. doi: 10.1128/JB.184.16.4640-4643.2002.


The Escherichia coli norVW genes encode a flavorubredoxin and NADH:(flavo)rubredoxin reductase, respectively, which are involved in nitric oxide detoxification under anaerobic growth conditions. Here it is shown that the norVW genes also have a role in protection against reactive nitrogen intermediates generated from nitroprusside. Transcription from the norV promoter is activated by the presence of nitroprusside in the growth medium; activation requires the product of a divergently transcribed regulatory gene, norR.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Base Sequence
  • DNA, Intergenic / genetics
  • Escherichia coli / enzymology*
  • Escherichia coli / genetics
  • Escherichia coli Proteins / genetics*
  • Escherichia coli Proteins / metabolism*
  • Gene Expression Regulation, Bacterial
  • Gene Expression Regulation, Enzymologic
  • Molecular Sequence Data
  • NADH, NADPH Oxidoreductases / genetics
  • NADH, NADPH Oxidoreductases / metabolism
  • Nitric Oxide / metabolism
  • Phenotype
  • Promoter Regions, Genetic / genetics
  • Reactive Nitrogen Species / metabolism*
  • Transcription Factors / genetics*
  • Transcription Factors / metabolism*


  • DNA, Intergenic
  • Escherichia coli Proteins
  • Reactive Nitrogen Species
  • Transcription Factors
  • YgaK protein, E coli
  • Nitric Oxide
  • rubredoxin-NAD+ reductase
  • NADH, NADPH Oxidoreductases