Function of pseudomonas porins in uptake and efflux

Annu Rev Microbiol. 2002;56:17-38. doi: 10.1146/annurev.micro.56.012302.160310. Epub 2002 Jan 30.


Porins are proteins that form water-filled channels across the outer membranes of Gram-negative bacteria and thus make this membrane semipermeable. There are four types of porins: general/nonspecific porins, substrate-specific porins, gated porins, and efflux porins (also called channel-tunnels). The recent publication of the genomic sequence of Pseudomonas aeruginosa PAO1 has dramatically increased our understanding of the porins of this organism. In particular this organism has 3 large families of porins: the OprD family of specific porins (19 members), the OprM family of efflux porins (18 members), and the TonB-interacting family of gated porins (35 members). These familial relationships underlie functional similarities such that well-studied members of these families become prototypes for other members. We summarize here the latest information on these porins.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Ion Channel Gating
  • Models, Molecular
  • Porins / classification
  • Porins / genetics*
  • Porins / physiology*
  • Pseudomonas aeruginosa / cytology
  • Pseudomonas aeruginosa / pathogenicity
  • Pseudomonas aeruginosa / physiology*


  • Porins