Applications of selective neutrality tests to molecular ecology

Mol Ecol. 2002 Aug;11(8):1245-62. doi: 10.1046/j.1365-294x.2002.01536.x.


This paper reviews how statistical tests of neutrality have been used to address questions in molecular ecology are reviewed. The work consists of four major parts: a brief review of the current status of the neutral theory; a review of several particularly interesting examples of how statistical tests of neutrality have led to insight into ecological problems; a brief discussion of the pitfalls of assuming a strictly neutral model if it is false; and a discussion of some of the opportunities and problems that molecular ecologists face when using neutrality tests to study natural selection.

Publication types

  • Review

MeSH terms

  • Animals
  • Ecology*
  • Evolution, Molecular
  • Humans
  • Models, Molecular
  • Molecular Biology*
  • Protein Structure, Tertiary
  • Selection, Genetic*