Efficient delivery of siRNA for inhibition of gene expression in postnatal mice

Nat Genet. 2002 Sep;32(1):107-8. doi: 10.1038/ng944. Epub 2002 Jul 29.


It has recently been shown that RNA interference can be induced in cultured mammalian cells by delivery of short interfering RNAs (siRNAs). Here we describe a method for efficient in vivo delivery of siRNAs to organs of postnatal mice and demonstrate effective and specific inhibition of transgene expression in a variety of organs.

MeSH terms

  • Animals
  • Animals, Newborn
  • Cnidaria
  • Coleoptera
  • Gene Expression Regulation*
  • Gene Transfer Techniques*
  • Green Fluorescent Proteins
  • Liver / metabolism
  • Luciferases / genetics
  • Luminescent Proteins / genetics
  • Mice
  • Plasmids
  • RNA, Small Interfering
  • RNA, Untranslated / administration & dosage*
  • Transgenes


  • Luminescent Proteins
  • RNA, Small Interfering
  • RNA, Untranslated
  • Green Fluorescent Proteins
  • Luciferases