Malignant transformation of a vestibular schwannoma after gamma knife radiosurgery

Lancet. 2002 Jul 27;360(9329):309-10. doi: 10.1016/S0140-6736(02)09521-1.


Stereotactic radiosurgery is used to treat benign tumours, but its long-term effects are not fully understood. Here we describe a vestibular schwannoma that underwent malignant transformation 6 years after gamma knife radiosurgery applied to the tumour remnant after a primary resection. Histological specimens of the original specimen did not show any atypical features. Genotyping showed a TP53 mutation in the recurrent tumour, which did not exist in the original tumour. Our results suggest that radiosurgery induced the malignant transformation, and we propose a cautious application of this treatment for benign tumours.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Cell Transformation, Neoplastic / genetics
  • Fatal Outcome
  • Female
  • Humans
  • Neoplasm Recurrence, Local / genetics
  • Neoplasm Recurrence, Local / pathology*
  • Neuroma, Acoustic / pathology*
  • Neuroma, Acoustic / surgery
  • Radiosurgery / adverse effects*
  • Radiosurgery / instrumentation