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Review
. 2002 Aug;72(2):233-8.

Interleukin-1 in the Genesis and Progression of and Risk for Development of Neuronal Degeneration in Alzheimer's Disease

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Free PMC article
Review

Interleukin-1 in the Genesis and Progression of and Risk for Development of Neuronal Degeneration in Alzheimer's Disease

W Sue T Griffin et al. J Leukoc Biol. .
Free PMC article

Abstract

Interleukin-1 (IL-1), a key molecule in systemic immune responses in health and disease, has analogous roles in the brain where it may contribute to neuronal degeneration. Numerous findings suggest that this is the case. For example, IL-1 overexpression in the brain of Alzheimer patients relates directly to the development and progression of the cardinal neuropathological changes of Alzheimer's disease, i.e., the genesis and accumulation of beta-amyloid (Abeta) plaques and the formation and accumulation of neurofibrillary tangles in neurons, both of which contribute to neuronal dysfunction and demise. Several genetic studies show that inheritance of a specific IL-1A gene polymorphism increases risk for development of Alzheimer's disease by as much as sixfold. Moreover, this increased risk is associated with earlier age of onset of the disease. Homozygosity for this polymorphism in combination with another in the IL-1B gene further increases risk.

Figures

Fig. 1
Fig. 1
Depiction of the ways in which IL-1 may be induced and amplified by and contribute to cellular injury. NO, nitric oxide; iNOS, inducible NO synthase. © University of Arkansas for Medical Sciences.

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