Medulloblastoma: a problem of developmental biology

Cancer Cell. 2002 Jul;2(1):7-8. doi: 10.1016/s1535-6108(02)00090-9.

Abstract

The identification of SUFU mutations in desmoplastic medulloblastoma provides new insights into vertebrate Hedgehog signaling and brain tumor formation.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Alleles
  • Cerebellar Neoplasms / genetics*
  • Cerebellar Neoplasms / metabolism
  • Child
  • Chromosomes, Human, Pair 10
  • Gene Expression Regulation, Developmental
  • Gene Expression Regulation, Neoplastic
  • Genes, Tumor Suppressor
  • Genetic Predisposition to Disease
  • Germ-Line Mutation
  • Hedgehog Proteins
  • Humans
  • Medulloblastoma / genetics*
  • Medulloblastoma / metabolism
  • Membrane Proteins / genetics*
  • Membrane Proteins / metabolism
  • Models, Genetic
  • Oncogene Proteins / metabolism
  • Patched Receptors
  • Receptors, Cell Surface / genetics*
  • Receptors, Cell Surface / metabolism
  • Receptors, G-Protein-Coupled*
  • Signal Transduction / genetics
  • Smoothened Receptor
  • Trans-Activators / genetics*
  • Trans-Activators / metabolism
  • Transcription Factors / metabolism
  • Zinc Finger Protein GLI1

Substances

  • Hedgehog Proteins
  • Membrane Proteins
  • Oncogene Proteins
  • Patched Receptors
  • Receptors, Cell Surface
  • Receptors, G-Protein-Coupled
  • SMO protein, human
  • Smoothened Receptor
  • Trans-Activators
  • Transcription Factors
  • Zinc Finger Protein GLI1