Abstract
The identification of SUFU mutations in desmoplastic medulloblastoma provides new insights into vertebrate Hedgehog signaling and brain tumor formation.
Publication types
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Alleles
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Cerebellar Neoplasms / genetics*
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Cerebellar Neoplasms / metabolism
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Child
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Chromosomes, Human, Pair 10
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Gene Expression Regulation, Developmental
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Gene Expression Regulation, Neoplastic
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Genes, Tumor Suppressor
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Genetic Predisposition to Disease
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Germ-Line Mutation
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Hedgehog Proteins
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Humans
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Medulloblastoma / genetics*
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Medulloblastoma / metabolism
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Membrane Proteins / genetics*
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Membrane Proteins / metabolism
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Models, Genetic
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Oncogene Proteins / metabolism
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Patched Receptors
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Receptors, Cell Surface / genetics*
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Receptors, Cell Surface / metabolism
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Receptors, G-Protein-Coupled*
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Signal Transduction / genetics
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Smoothened Receptor
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Trans-Activators / genetics*
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Trans-Activators / metabolism
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Transcription Factors / metabolism
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Zinc Finger Protein GLI1
Substances
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Hedgehog Proteins
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Membrane Proteins
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Oncogene Proteins
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Patched Receptors
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Receptors, Cell Surface
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Receptors, G-Protein-Coupled
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SMO protein, human
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Smoothened Receptor
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Trans-Activators
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Transcription Factors
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Zinc Finger Protein GLI1