Abstract
Biological assay guided fractionation of a dichloromethane extract of Synaptolepis kirkii led to the isolation of four new and five known daphnane-type diterpene orthoesters, whose structure was established by spectroscopic data. Full spectroscopic data of the new and known natural products are reported here for the first time. Pronounced neurotrophic and substantial antileukaemia activities of these compounds were found in in vitro assays.
MeSH terms
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Animals
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Antineoplastic Agents, Phytogenic / chemistry
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Antineoplastic Agents, Phytogenic / isolation & purification*
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Antineoplastic Agents, Phytogenic / pharmacology
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Cell Survival / drug effects
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Chick Embryo
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Diterpenes / chemistry
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Diterpenes / isolation & purification
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Diterpenes / pharmacology
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Ganglia, Spinal / cytology
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Ganglia, Spinal / drug effects
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Humans
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Leukemia / drug therapy
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Models, Molecular
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Molecular Structure
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Nerve Growth Factors / chemistry
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Nerve Growth Factors / isolation & purification*
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Nerve Growth Factors / pharmacology
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Neurons / drug effects
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Terpenes / chemistry
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Terpenes / isolation & purification
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Terpenes / pharmacology
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Thymelaeaceae / chemistry
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Triterpenes / chemistry
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Triterpenes / isolation & purification
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Triterpenes / pharmacology
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Tumor Cells, Cultured
Substances
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Antineoplastic Agents, Phytogenic
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Diterpenes
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Nerve Growth Factors
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Terpenes
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Triterpenes
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kirkinine
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mezerein