Autoreactive CD8 T cells in organ-specific autoimmunity: emerging targets for therapeutic intervention

Immunity. 2002 Jul;17(1):1-6. doi: 10.1016/s1074-7613(02)00338-2.


The importance of CD8 T cells in the pathogenesis of organ-specific autoimmune diseases has not previously been well recognized. Recent evidence, however, indicates that autoreactive CD8 T cells can contribute substantially to tissue damage in both murine and human autoimmune disorders. As such, these T cells now become an attractive target for therapeutic intervention.

Publication types

  • Review

MeSH terms

  • Animals
  • Autoimmune Diseases / immunology*
  • Autoimmune Diseases / therapy
  • Autoimmunity
  • CD8-Positive T-Lymphocytes / immunology*
  • Drug Delivery Systems
  • Humans
  • Lymphocyte Activation
  • Mice
  • Models, Immunological
  • Organ Specificity