Initiation of NALT organogenesis is independent of the IL-7R, LTbetaR, and NIK signaling pathways but requires the Id2 gene and CD3(-)CD4(+)CD45(+) cells

Immunity. 2002 Jul;17(1):31-40. doi: 10.1016/s1074-7613(02)00339-4.

Abstract

Initiation of nasopharyngeal-associated lymphoid tissue (NALT) development is independent of the programmed cytokine cascade necessary for the formation of Peyer's patches (PP) and peripheral lymph nodes (PLN), a cytokine cascade which consists of IL-7R, LTalpha1beta2/LTbetaR, and NIK. However, the subsequent organization of NALT seems to be controlled by these cytokine signaling cascades since the maturation of NALT structure is generally incomplete in those cytokine cascade-deficient mice. NALT as well as PP and PLN are completely absent in Id2(-/-) mice. NALT organogenesis is initiated following the adoptive transfer of CD3(-)CD4(+)CD45(+) cells into Id2(-/-) mice, constituting direct evidence that CD3(-)CD4(+)CD45(+) inducer cells can provide an IL-7R-, LTalpha1beta2/LTbetaR-, and NIK-independent tissue organogenesis pathway for secondary lymphoid tissue development.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adoptive Transfer
  • Animals
  • Animals, Newborn
  • Antigens, Surface / analysis
  • Antigens, Surface / physiology
  • CD3 Complex / analysis
  • CD4-Positive T-Lymphocytes / immunology*
  • CD4-Positive T-Lymphocytes / transplantation
  • DNA-Binding Proteins / genetics
  • DNA-Binding Proteins / physiology*
  • Inhibitor of Differentiation Protein 2
  • L-Selectin / physiology
  • Leukocyte Common Antigens / analysis
  • Lymphoid Tissue / anatomy & histology
  • Lymphoid Tissue / growth & development*
  • Lymphotoxin beta Receptor
  • Membrane Proteins
  • Mice
  • Mice, Inbred C57BL
  • Mice, Knockout
  • Models, Immunological
  • Nasopharynx / anatomy & histology
  • Nasopharynx / growth & development
  • Nasopharynx / immunology*
  • Peyer's Patches / anatomy & histology
  • Peyer's Patches / growth & development
  • Protein-Serine-Threonine Kinases / physiology
  • Receptors, Interleukin-7 / physiology
  • Receptors, Tumor Necrosis Factor / physiology
  • Repressor Proteins*
  • Signal Transduction*
  • Transcription Factors / genetics
  • Transcription Factors / physiology*

Substances

  • Antigens, Surface
  • CD3 Complex
  • DNA-Binding Proteins
  • Idb2 protein, mouse
  • Inhibitor of Differentiation Protein 2
  • L-selectin counter-receptors
  • Ltbr protein, mouse
  • Lymphotoxin beta Receptor
  • Membrane Proteins
  • Receptors, Interleukin-7
  • Receptors, Tumor Necrosis Factor
  • Repressor Proteins
  • Transcription Factors
  • L-Selectin
  • Protein-Serine-Threonine Kinases
  • NF-kappa B kinase
  • Leukocyte Common Antigens