Memory CD8(+) T cells undergo peripheral tolerance

Immunity. 2002 Jul;17(1):73-81. doi: 10.1016/s1074-7613(02)00337-0.


Memory T cells differ from naive T cells in that they respond more rapidly and in greater numbers. In addition, memory T cells are generally believed to be less susceptible to tolerance induction than naive T cells. In this study, we show that this is not the case. Using two different methods of tolerance induction, peptide-induced tolerance and crosstolerance, we present evidence that memory CD8(+) T cells are as susceptible to tolerance as naive cells. These results have a direct impact on manipulating T cell responses to self-antigens in order to improve immunotherapy of cancer and autoimmune diseases.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Animals, Newborn
  • Autoantigens / immunology
  • Cell Line
  • Clone Cells
  • Diabetes Mellitus / immunology
  • Genes, T-Cell Receptor
  • Hemagglutinins / immunology
  • Hemagglutinins / metabolism
  • Immune Tolerance*
  • Immunologic Memory*
  • Lymph Nodes / immunology
  • Mice
  • Mice, Inbred BALB C
  • Pancreas / immunology
  • Peptides / immunology
  • T-Lymphocytes, Cytotoxic / immunology*


  • Autoantigens
  • Hemagglutinins
  • Peptides