The two faces of BRCA2, a FANCtastic discovery

Mol Cell. 2002 Jul;10(1):2-4. doi: 10.1016/s1097-2765(02)00580-4.


The molecular defects responsible for the cancer predisposition syndrome Fanconi's Anemia (FA) have been elusive. A recent study reports that the FANC-B and -D1 subgroups result from hypomorphic mutations in BRCA2. Given that BRCA2 protein participates in homologous recombination, this finding connects at least a subset of the FA phenotypes to defective DNA repair.

MeSH terms

  • Animals
  • BRCA2 Protein / genetics*
  • DNA Damage*
  • DNA Repair*
  • Fanconi Anemia / genetics*
  • Fanconi Anemia / pathology
  • Fanconi Anemia Complementation Group D2 Protein
  • Genetic Predisposition to Disease / genetics*
  • Humans
  • Mitomycin / pharmacology
  • Nuclear Proteins / genetics
  • Nuclear Proteins / metabolism


  • BRCA2 Protein
  • FANCD2 protein, human
  • Fanconi Anemia Complementation Group D2 Protein
  • Nuclear Proteins
  • Mitomycin