Smad about E2F. TGFbeta repressionof c-Myc via a Smad3/E2F/p107 complex

Mol Cell. 2002 Jul;10(1):7-8. doi: 10.1016/s1097-2765(02)00584-1.


Signaling by TGFbeta regulates the expression of hundreds of genes. The rapid repression of c-Myc stands out because of its roles in growth control and cancer. Recent work shows that c-Myc repression by TGFbeta is mediated by the nuclear translocation of a novel, preformed complex composed of Smad3, E2F4 or E2F5, and the Rb-related factor p107.

MeSH terms

  • Animals
  • DNA-Binding Proteins / metabolism*
  • E2F4 Transcription Factor
  • Gene Expression Regulation / drug effects*
  • Macromolecular Substances
  • Models, Biological
  • Nuclear Proteins / metabolism*
  • Proto-Oncogene Proteins c-myc / metabolism*
  • Signal Transduction / drug effects
  • Smad3 Protein
  • Trans-Activators / metabolism*
  • Transcription Factors / metabolism*
  • Transforming Growth Factor beta / pharmacology*


  • DNA-Binding Proteins
  • E2F4 Transcription Factor
  • Macromolecular Substances
  • Nuclear Proteins
  • Proto-Oncogene Proteins c-myc
  • Smad3 Protein
  • Trans-Activators
  • Transcription Factors
  • Transforming Growth Factor beta