Exploring the Neighborhood: Adhesion-Coupled Cell Mechanosensors

Cell. 2002 Jul 26;110(2):139-42. doi: 10.1016/s0092-8674(02)00831-0.

Abstract

Here we discuss recent studies addressing adhesion-coupled mechanosensory processes and consider their molecular nature. Are cells using stretch-activated ion channels to explore the extracellular environment surrounding them, or do they use for that purpose the submembrane protein network that interconnects integrin receptors with the actin cytoskeleton?

Publication types

  • Review

MeSH terms

  • Animals
  • Cell Adhesion / physiology
  • Focal Adhesions / physiology*
  • Mechanoreceptors / metabolism*