Evidence for a mediator of RNA polymerase II transcriptional regulation conserved from yeast to man

Cell. 2002 Jul 26;110(2):143-51. doi: 10.1016/s0092-8674(02)00830-9.


Mediator complexes (MED) link transcriptional regulators to RNA polymerase II. Here, we summarize the latest advances on the functional organization of yeast Mediator. We argue for the existence of a "universal" Mediator structurally conserved from yeast to man, based on an extensive analysis of sequence databases. Finally, we examine the implications of these observations for the physiological roles of metazoan MED subunits.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Conserved Sequence*
  • Eukaryotic Cells
  • Fungal Proteins / genetics*
  • Fungal Proteins / metabolism
  • Fungal Proteins / physiology
  • Humans
  • Molecular Sequence Data
  • RNA Polymerase II / chemistry
  • RNA Polymerase II / metabolism*
  • Sequence Homology, Amino Acid
  • Transcription Factors / genetics*
  • Transcription Factors / metabolism
  • Transcription Factors / physiology
  • Transcription, Genetic*
  • Yeasts / genetics


  • Fungal Proteins
  • Transcription Factors
  • RNA Polymerase II