SWIM, a novel Zn-chelating domain present in bacteria, archaea and eukaryotes
- PMID: 12151216
- DOI: 10.1016/s0968-0004(02)02140-0
SWIM, a novel Zn-chelating domain present in bacteria, archaea and eukaryotes
Abstract
A previously undetected domain with a CxCx(n)CxH pattern of predicted zinc-chelating residues was identified in a variety of prokaryotic and eukaryotic proteins. These include bacterial ATPases of the SWI2/SNF2 family, plant MuDR transposases and transposase-derived Far1 nuclear proteins, and vertebrate MEK kinase-1. This domain was designated SWIM after SWI2/SNF2 and MuDR, and is predicted to have DNA-binding and protein-protein interaction functions in different contexts.
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