SWIM, a novel Zn-chelating domain present in bacteria, archaea and eukaryotes

Trends Biochem Sci. 2002 Aug;27(8):384-6. doi: 10.1016/s0968-0004(02)02140-0.

Abstract

A previously undetected domain with a CxCx(n)CxH pattern of predicted zinc-chelating residues was identified in a variety of prokaryotic and eukaryotic proteins. These include bacterial ATPases of the SWI2/SNF2 family, plant MuDR transposases and transposase-derived Far1 nuclear proteins, and vertebrate MEK kinase-1. This domain was designated SWIM after SWI2/SNF2 and MuDR, and is predicted to have DNA-binding and protein-protein interaction functions in different contexts.

Publication types

  • Review

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Archaeal Proteins / chemistry
  • Archaeal Proteins / metabolism*
  • Bacterial Proteins / chemistry
  • Bacterial Proteins / metabolism*
  • Binding Sites
  • Cell Cycle Proteins*
  • Cyclin-Dependent Kinase Inhibitor Proteins
  • DNA / metabolism
  • DNA-Binding Proteins / metabolism*
  • Eukaryotic Cells / chemistry
  • Fungal Proteins / chemistry
  • Fungal Proteins / metabolism
  • MAP Kinase Kinase Kinase 1*
  • Molecular Sequence Data
  • Nuclear Proteins*
  • Plant Proteins / chemistry
  • Plant Proteins / metabolism
  • Protein Structure, Tertiary
  • Protein-Serine-Threonine Kinases / chemistry
  • Protein-Serine-Threonine Kinases / metabolism*
  • Repressor Proteins*
  • Saccharomyces cerevisiae Proteins*
  • Sequence Homology, Amino Acid
  • Transcription Factors / metabolism*
  • Transposases / chemistry
  • Transposases / metabolism
  • Vertebrates
  • Zinc / metabolism*

Substances

  • Archaeal Proteins
  • Bacterial Proteins
  • Cell Cycle Proteins
  • Cyclin-Dependent Kinase Inhibitor Proteins
  • DNA-Binding Proteins
  • FAR1 protein, S cerevisiae
  • Fungal Proteins
  • Nuclear Proteins
  • Plant Proteins
  • Repressor Proteins
  • Saccharomyces cerevisiae Proteins
  • Transcription Factors
  • DNA
  • Protein-Serine-Threonine Kinases
  • MAP Kinase Kinase Kinase 1
  • MAP3K1 protein, human
  • Transposases
  • Zinc