Association of gammaA/gamma' fibrinogen levels and coronary artery disease

Thromb Haemost. 2002 Jul;88(1):26-31.


GammaA/gamma' fibrinogen is a fibrinogen isoform that constitutes about 15% of total plasma fibrinogen. This isoform contains an additional binding site for zymogen factor XIII and for active thrombin, and forms fibrin clots that are resistant to fibrinolysis in vitro. Little is known about the variability of gammaA/gamma' fibrinogen levels in human populations, whereas total fibrinogen levels are known to increase with age and are higher in women than in men. In this report, evidence is presented that, in contrast to total fibrinogen levels, gammaA/gamma' fibrinogen levels showed no significant association with age or gender in a population of normal blood donors. A study of gammaA/gamma' fibrinogen levels in patients undergoing coronary angiography also showed that gammaA/gamma' fibrinogen levels were higher on average in coronary artery disease patients than in patients without coronary artery disease, and that this association was independent of total fibrinogen levels.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adult
  • Age Factors
  • Aged
  • Aged, 80 and over
  • Alternative Splicing
  • Case-Control Studies
  • Coronary Artery Disease / blood*
  • Female
  • Fibrinogen / analysis*
  • Fibrinogen / genetics
  • Humans
  • Male
  • Middle Aged
  • RNA, Messenger / genetics
  • Regression Analysis
  • Sex Factors


  • RNA, Messenger
  • fibrinopeptides gamma
  • Fibrinogen