Abstract
In search for novel conformationally constrained analogues of L-glutamic acid, a diastereodivergent synthesis of the four 1-aminospiro[2.2]pentyl-1,4-dicarboxylic acid racemic pairs is reported along with their stereochemical assignment, conformational analysis, and preliminary biological evaluation as potential glutamate (ionotropic and metabotropic) ligands.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Dicarboxylic Acids / chemical synthesis*
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Dicarboxylic Acids / chemistry
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Glutamic Acid / analogs & derivatives*
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Glutamic Acid / chemistry*
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Models, Molecular
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Molecular Conformation
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Pentanes / chemistry*
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Spiro Compounds / chemical synthesis*
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Spiro Compounds / chemistry
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Stereoisomerism
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Structure-Activity Relationship
Substances
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Dicarboxylic Acids
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Pentanes
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Spiro Compounds
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Glutamic Acid