ERM Proteins and Merlin: Integrators at the Cell Cortex

Nat Rev Mol Cell Biol. 2002 Aug;3(8):586-99. doi: 10.1038/nrm882.

Abstract

A fundamental property of many plasma-membrane proteins is their association with the underlying cytoskeleton to determine cell shape, and to participate in adhesion, motility and other plasma-membrane processes, including endocytosis and exocytosis. The ezrin-radixin-moesin (ERM) proteins are crucial components that provide a regulated linkage between membrane proteins and the cortical cytoskeleton, and also participate in signal-transduction pathways. The closely related tumour suppressor merlin shares many properties with ERM proteins, yet also provides a distinct and essential function.

Publication types

  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Blood Proteins / metabolism*
  • Cell Line
  • Cell Membrane / metabolism
  • Cell Polarity
  • Cytoskeletal Proteins / metabolism*
  • Cytoskeleton / metabolism*
  • Humans
  • Membrane Proteins / metabolism*
  • Microfilament Proteins / metabolism*
  • Models, Biological
  • Multigene Family
  • Neurofibromin 2 / metabolism*
  • Phosphoproteins / metabolism*
  • Phylogeny
  • Protein Structure, Tertiary
  • Signal Transduction / physiology
  • Tumor Suppressor Proteins / metabolism

Substances

  • Blood Proteins
  • Cytoskeletal Proteins
  • Membrane Proteins
  • Microfilament Proteins
  • Neurofibromin 2
  • Phosphoproteins
  • Tumor Suppressor Proteins
  • ezrin
  • moesin
  • radixin