Signal transduction and endocytosis: close encounters of many kinds

Nat Rev Mol Cell Biol. 2002 Aug;3(8):600-14. doi: 10.1038/nrm883.


Binding of hormones, growth factors and other cell modulators to cell-surface receptors triggers a complex array of signal-transduction events. The activation of many receptors also accelerates their endocytosis. Endocytic transport is important in regulating signal transduction and in mediating the formation of specialized signalling complexes. Conversely, signal-transduction events modulate specific components of the endocytic machinery. Recent studies of protein tyrosine kinases and G-protein-coupled receptors have shed new light on the mechanisms and functional consequences of this bidirectional interplay between signalling and membrane-transport networks.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Biological Transport / physiology
  • Endocytosis / physiology*
  • Endosomes / metabolism
  • Ligands
  • Macromolecular Substances
  • Membrane Proteins / metabolism
  • Models, Biological
  • Protein Transport / physiology
  • Receptors, Cell Surface / metabolism*
  • Receptors, Notch
  • Signal Transduction / physiology*


  • Ligands
  • Macromolecular Substances
  • Membrane Proteins
  • Receptors, Cell Surface
  • Receptors, Notch