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, 12 (17), 2399-402

C-3 Amido-indole Cannabinoid Receptor Modulators

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C-3 Amido-indole Cannabinoid Receptor Modulators

John Hynes Jr et al. Bioorg Med Chem Lett.

Abstract

C-3 Amido-indoles were found to selectively bind to the CB2 receptor. SAR studies led to optimized compounds with excellent in vivo potency against LPS induced TNF-alpha release in murine models of cytokine production.

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