Clinical implications of statin event trials

Curr Atheroscler Rep. 2002 Sep;4(5):337-42. doi: 10.1007/s11883-002-0070-y.

Abstract

Event trials using statin therapy have shown a beneficial effect on rates of cardiovascular events. The three statins that have been used in long-term trials have shown generally similar effects on rates of myocardial infarction, stroke, revascularizations, and mortality. Safety data appear to be comparable for lovastatin, pravastatin, and simvastatin. Long-term trials of other statins are in progress or pending. The question of how much low-density lipoprotein cholesterol should be lowered may be answered by studies currently in progress.

Publication types

  • Meta-Analysis

MeSH terms

  • Coronary Disease / mortality
  • Coronary Disease / prevention & control*
  • Dose-Response Relationship, Drug
  • Drug Administration Schedule
  • Female
  • Follow-Up Studies
  • Humans
  • Hydroxymethylglutaryl-CoA Reductase Inhibitors / therapeutic use*
  • Hyperlipidemias / diagnosis
  • Hyperlipidemias / drug therapy*
  • Hyperlipidemias / mortality
  • Male
  • Primary Prevention / methods
  • Randomized Controlled Trials as Topic
  • Risk Assessment
  • Severity of Illness Index
  • Survival Analysis
  • Treatment Outcome

Substances

  • Hydroxymethylglutaryl-CoA Reductase Inhibitors