Rotamer libraries in the 21st century

Curr Opin Struct Biol. 2002 Aug;12(4):431-40. doi: 10.1016/s0959-440x(02)00344-5.


Rotamer libraries are widely used in protein structure prediction, protein design, and structure refinement. As the size of the structure data base has increased rapidly in recent years, it has become possible to derive well-refined rotamer libraries using strict criteria for data inclusion and for studying dependence of rotamer populations and dihedral angles on local structural features.

Publication types

  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Amino Acids / chemistry*
  • Databases, Protein*
  • Information Storage and Retrieval / methods
  • Information Storage and Retrieval / trends*
  • Peptide Library*
  • Protein Conformation
  • Protein Folding*
  • Proteins / chemistry*


  • Amino Acids
  • Peptide Library
  • Proteins