Cancer cachexia

Int J Cardiol. 2002 Sep;85(1):73-81. doi: 10.1016/s0167-5273(02)00235-8.


Cancer cachexia is a complex, multifactorial syndrome that results from a reduction in food intake, a variety of metabolic abnormalities (including hypermetabolism) or more often a combination of the two. Multiple mediator pathways including pro-inflammatory cytokines, neuroendocrine hormones and tumour-specific factors are involved. Therapy requires a multi-model approach that addresses both reduced food intake and metabolic change. Combination treatments such as nutritional support plus metabolic/inflammation modulation promise improved functional capacity and quality of life.

Publication types

  • Review

MeSH terms

  • Cachexia / epidemiology
  • Cachexia / etiology*
  • Cachexia / therapy
  • Humans
  • Incidence
  • Neoplasms / complications*
  • Neoplasms / epidemiology
  • Neoplasms / therapy
  • Quality of Life