Synthesis and antituberculosis activity of new N-phenyl-N'-[4-(5-alkyl/arylamino-1,3,4-thiadiazole-2-yl)phenyl]thioureas

S Karakuş; S Rollas

doi:10.1016/s0014-827x(02)01252-1

Synthesis and antituberculosis activity of new N-phenyl-N'-[4-(5-alkyl/arylamino-1,3,4-thiadiazole-2-yl)phenyl]thioureas

Farmaco. 2002 Jul;57(7):577-81. doi: 10.1016/s0014-827x(02)01252-1.

Authors

S Karakuş¹, S Rollas

Affiliation

¹ Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Marmara University, Haydarpaşa, Istanbul, Turkey.

PMID: 12164218
DOI: 10.1016/s0014-827x(02)01252-1

Abstract

In this study, eight original N-phenyl-N'-[4-(5-alkyl/arylamino-1,3,4-thiadiazole-2-yl)phenyl]thiourea derivatives were synthesized and tested for antituberculosis activity. Antituberculosis activities of the synthesized compounds were screened in vitro using BACTEC 460 Radiometric System against Mycobacterium tuberculosis H37Rv at 6.25 microg/ml. The highest inhibition observed with the synthesized compounds is 67% for N-phenyl-N'-[4-(5-cyclohexylamino-1,3,4-thiadiazole-2-yl)phenyl]thiourea.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Antitubercular Agents / chemical synthesis*
Antitubercular Agents / chemistry
Antitubercular Agents / pharmacology
Drug Resistance, Microbial
Magnetic Resonance Spectroscopy
Microbial Sensitivity Tests
Molecular Structure
Mycobacterium tuberculosis / drug effects*
Structure-Activity Relationship
Thiourea / analogs & derivatives*
Thiourea / chemical synthesis*
Thiourea / pharmacology

Substances

Antitubercular Agents
Thiourea