Health-related quality of life in patients with primary Sjögren's syndrome and xerostomia: a comparative study

Gerodontology. 2002 Jul;19(1):53-9. doi: 10.1111/j.1741-2358.2002.00053.x.


Objective: To compare the health status of groups of Primary Sjögren's and Xerostomia patients, using the Medical Outcomes Short Form 36 (SF-36). The SF-36 is a generic measure, divided into eight domains, used in the assessment of health-related quality of life.

Patients and methods: The SF-36 was given to 2 groups: Group 1 comprised 43 patients diagnosed with Primary Sjögren's Syndrome (1 degrees SS) and an unstimulated whole salivary flow rate (UFR) of <0.1 ml/min). Group 2 (n = 40) reported Xerostomia but had an UFR >0.2 ml/min. Sub groups of patients in Groups 1 and 2 were compared with community normative data, for the SF-36.

Results: There were trends to suggest lower SF36 scores for 1 degrees SS patients but there were no significant differences between the mean domain scores of Groups 1 and 2. 1 degrees SS and Xerostomia patients registered lower mean scores across all 8 domains, compared with normative community data.

Conclusion: The SF-36 was unable to detect significant differences between subjects with 1 degrees SS and Xerostomia but a larger sample size is required to confirm these findings. The results of this limited study suggest that a disease-specific measure is required to assess the impact 1 degrees SS on health-related Quality of life (QOL).

Publication types

  • Comparative Study

MeSH terms

  • Activities of Daily Living
  • Adult
  • Aged
  • Aged, 80 and over
  • Attitude to Health
  • Confidence Intervals
  • Female
  • Health Status
  • Humans
  • Male
  • Matched-Pair Analysis
  • Middle Aged
  • Quality of Life*
  • Saliva / metabolism
  • Secretory Rate / physiology
  • Sjogren's Syndrome / physiopathology
  • Sjogren's Syndrome / psychology*
  • Statistics as Topic
  • Statistics, Nonparametric
  • Xerostomia / physiopathology
  • Xerostomia / psychology*