Tumor lysis syndrome following endoscopic radiofrequency interstitial thermal ablation of colorectal liver metastases

Surg Endosc. 2002 Jul;16(7):1109. doi: 10.1007/s00464-001-4246-2. Epub 2002 Apr 9.


Radiofrequency interstitial thermal ablation (RITA) provides a palliative option for patients suffering from metastatic liver disease. This procedure can be performed using a laparoscopic approach with laparoscopic ultrasound used to position the RITA probe. We describe a case of laparoscopic RITA performed for colorectal liver metastasis that was complicated by tumor lysis syndrome (TLS) following treatment. We consider RITA to be a safe procedure, as supported by the literature, but where intracorporal tumor lysis is the treatment goal we believe that the systemic release of tumor products can overwhelm the excretory capacity; therefore, TLS is an inevitable consequence in some patients.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Catheter Ablation / adverse effects*
  • Catheter Ablation / methods
  • Cecal Neoplasms / pathology
  • Cecal Neoplasms / surgery
  • Colectomy
  • Colorectal Neoplasms / pathology*
  • Colorectal Neoplasms / surgery*
  • Endoscopy / adverse effects*
  • Endoscopy / methods
  • Female
  • Humans
  • Intestinal Obstruction / etiology
  • Intestinal Obstruction / pathology
  • Intestinal Obstruction / surgery
  • Liver Neoplasms / secondary*
  • Liver Neoplasms / surgery*
  • Postoperative Complications / etiology*
  • Tumor Lysis Syndrome / etiology*