Preferential orientation of natural lambdoid prophages and bacterial chromosome organization

Allan M Campbell

doi:10.1006/tpbi.2002.1604

Preferential orientation of natural lambdoid prophages and bacterial chromosome organization

Theor Popul Biol. 2002 Jun;61(4):503-7. doi: 10.1006/tpbi.2002.1604.

Author

Allan M Campbell¹

Affiliation

¹ Department of Biological Sciences, Stanford University, California 94305-5020, USA.

PMID: 12167370
DOI: 10.1006/tpbi.2002.1604

Abstract

All known lambdoid prophages of Escherichia coli have the same orientation with respect to direction of chromosomal replication. This includes 12 prophages that are replicated in one direction and five in the other. Among candidate explanations, the most amenable to experimental study is an effect on dif site function in assuring chromosomal segregation. This is but one of numerous examples of strand bias in the E. coli genome, all of which may interact with one another.

Publication types

Research Support, U.S. Gov't, P.H.S.
Review

MeSH terms

Bacteriophage lambda / genetics*
Chromosomes, Bacterial*
Escherichia coli / virology*

Grants and funding

GM 10452/GM/NIGMS NIH HHS/United States