A randomised, controlled study of dietary intervention in autistic syndromes

Nutr Neurosci. 2002 Sep;5(4):251-61. doi: 10.1080/10284150290028945.


Impaired social interaction, communication and imaginative skills characterize autistic syndromes. In these syndromes urinary peptide abnormalities, derived from gluten, gliadin, and casein, are reported. They reflect processes with opioid effect. The aim of this single blind study was to evaluate effect of gluten and casein-free diet for children with autistic syndromes and urinary peptide abnormalities. A randomly selected diet and control group with 10 children in each group participated. Observations and tests were done before and after a period of 1 year. The development for the group of children on diet was significantly better than for the controls.

Publication types

  • Clinical Trial
  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Autistic Disorder / diet therapy*
  • Autistic Disorder / physiopathology
  • Autistic Disorder / psychology
  • Behavior
  • Caseins / administration & dosage
  • Child
  • Child, Preschool
  • Cognition
  • Facial Expression
  • Glutens / administration & dosage
  • Humans
  • Interpersonal Relations
  • Language Disorders
  • Motor Activity
  • Peptides / urine
  • Sensation


  • Caseins
  • Peptides
  • Glutens