Synthesis of taurospongin A: a potent inhibitor of DNA polymerase and HIV reverse transcriptase, using pi-allyltricarbonyliron lactone complexes

Chem Commun (Camb). 2002 Aug 7;(15):1624-5. doi: 10.1039/b204994p.

Abstract

The synthesis of taurospongin A has been achieved using, as a key step, a pi-allyltricarbonyliron lactone complex to control a highly stereoselective addition of a methyl group to a carbonyl unit located in the side chain of the complex.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alkynes / chemical synthesis*
  • Animals
  • Enzyme Inhibitors / chemical synthesis*
  • Esters / chemical synthesis*
  • Indicators and Reagents
  • Iron Compounds
  • Lactones
  • Magnetic Resonance Spectroscopy
  • Nucleic Acid Synthesis Inhibitors*
  • Porifera / chemistry*
  • Reverse Transcriptase Inhibitors / chemical synthesis*

Substances

  • Alkynes
  • Enzyme Inhibitors
  • Esters
  • Indicators and Reagents
  • Iron Compounds
  • Lactones
  • Nucleic Acid Synthesis Inhibitors
  • Reverse Transcriptase Inhibitors
  • taurospongin A