Elevated serum C-reactive protein levels and early arterial changes in healthy children

Arterioscler Thromb Vasc Biol. 2002 Aug 1;22(8):1323-8. doi: 10.1161/01.atv.0000024222.06463.21.


Objective: Elevated serum concentration of C-reactive protein (CRP) predicts cardiovascular events in adults. Because atherosclerosis begins in childhood, we undertook a study to determine whether changes in brachial artery endothelial function and the thickness of the carotid intima-media complex, 2 markers of early atherosclerosis, are related to CRP levels in healthy children.

Methods and results: Brachial artery flow-mediated dilatation (FMD) and carotid artery intima-media thickness (IMT) were measured with ultrasound in 79 children (aged 10.5+/-1.1 years). Compared with the children with CRP levels under the detection limit (<0.1 mg/L, n=40, group 1), the children with higher CRP (0.1 mg/L< or =CRP< or =0.7 mg/L, n=20, group 2; CRP >0.7 mg/L, n=19, group 3) had lower FMD (9.0+/-4.4% versus 7.8+/-3.3% versus 6.5+/-2.6%, respectively; P=0.015 for trend) and greater carotid IMT (0.45+/-0.03 versus 0.46+/-0.04 versus 0.49+/-0.06 mm, respectively, P=0.002 for trend). CRP level remained a statistically significant independent predictor for brachial FMD and carotid IMT in multivariate analyses.

Conclusions: These data suggest that CRP affects the arteries of healthy children by disturbing endothelial function and promoting intima-media thickening. The findings support the hypothesis that CRP plays a role in the pathogenesis of early atherosclerosis.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Arteriosclerosis / blood
  • Arteriosclerosis / pathology
  • Biomarkers
  • Brachial Artery / anatomy & histology*
  • Brachial Artery / diagnostic imaging
  • Brachial Artery / physiology
  • C-Reactive Protein / metabolism*
  • Carotid Arteries / anatomy & histology*
  • Carotid Arteries / diagnostic imaging
  • Carotid Arteries / physiology
  • Child
  • Endothelium, Vascular / physiology*
  • Humans
  • Reference Values
  • Risk Factors
  • Tunica Intima / anatomy & histology*
  • Tunica Intima / diagnostic imaging
  • Tunica Intima / physiology
  • Ultrasonography


  • Biomarkers
  • C-Reactive Protein