Variation of venous admixture, SF6 shunt, PaO2, and the PaO2/FIO2 ratio with FIO2

Br J Anaesth. 2002 Jun;88(6):771-8. doi: 10.1093/bja/88.6.771.


Background: Measures of impairment of oxygenation can be affected by the inspired oxygen fraction.

Methods: We used a mathematical model of an inhomogenous lung to predict the effect of increasing inspired oxygen concentration (FIO2) on: (1) venous admixture (Qva/Qt); (2) arterial oxygen partial pressure (PaO2); (3) the PaO2/FIO2 index of hypoxaemia; and (4) sulphur hexafluoride (SF6) retention (often taken to be true right-to-left shunt). This model predicts whether or not atelectasis will occur.

Results: For lungs with regions of low V/Q, increasing the inspired oxygen concentration can cause these regions to collapse. In the absence of atelectasis, the model predicts that Qva/Qt will decrease and arterial oxygen partial pressure increase as FIO2 is increased. However, when atelectasis occurs, Qva/Qt rises to a constant value, whilst PaO2 falls at first, but then begins to rise again, with increasing FIO2. The SF6 retention increased markedly in some cases at high FIO2.

Conclusions: Venous admixture will estimate true right-to-left shunt at high FIO2, even when oxygen consumption is raised. This model can explain the way that the Pa/Fl ratio changes with increasing inspired oxygen concentration.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Computer Simulation
  • Humans
  • Hypoxia / blood
  • Hypoxia / physiopathology*
  • Models, Biological*
  • Oxygen / administration & dosage
  • Oxygen / blood*
  • Partial Pressure
  • Pulmonary Atelectasis / physiopathology
  • Pulmonary Gas Exchange*
  • Sulfur Hexafluoride / pharmacokinetics*


  • Oxygen
  • Sulfur Hexafluoride