A rare case of advanced male breast cancer in a patient on hemodialysis was successfully treated with radical mastectomy and chemotherapy. Computed tomography of the chest revealed multiple pulmonary metastases. After administration of chemotherapy consisting of 5-fluorouracil (4000 mg) and epirubicin (280 mg), the pulmonary metastases disappeared and this was associated with a decrease of serum CEA levels and tumor size. Radical mastectomy and reconstruction for the chest wall defect using a deltopectoral flap (DP flap) were performed. Histopathological examination of the resected specimen showed intraductal adenocarcinoma with nodal metastases. The patient has remained well without clinical recurrence of distant metastasis for a follow-up period of two years. Our experience has demonstrated that the DP flap was a feasible approach in male breast reconstruction despite the debilitated condition of the patient.