Cloning of zebrafish T-box genes tbx15 and tbx18 and their expression during embryonic development

Mech Dev. 2002 Jun;114(1-2):137-41. doi: 10.1016/s0925-4773(02)00040-0.


Members of the T-box (tbx) gene family encode developmentally regulated transcription factors, several of which are implicated in human hereditary diseases. We have cloned the paralogous genes tbx15 and tbx18 in zebrafish and have characterised their expression in detail. tbx15 is expressed in paraxial head mesenchyme and its derivatives, the extraocular and jaw musculature and the posterior neurocranium. Further areas of tbx15 expression are in the anterior somitic mesoderm, in periocular mesenchyme and in the pectoral fin mesenchyme throughout larval development. Areas of strong tbx18 expression are found in the developing somitic and presomitic mesoderm, in the heart and in pectoral fin mesenchyme, as well as the ventral neuroectoderm and the developing palate. Both genes exhibit particular differences in expression compared to their murine orthologs.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Cloning, Molecular
  • Gene Expression Regulation, Developmental*
  • Heart / embryology
  • In Situ Hybridization
  • Mesoderm / metabolism
  • Mice
  • Molecular Sequence Data
  • Phylogeny
  • T-Box Domain Proteins / biosynthesis
  • T-Box Domain Proteins / genetics*
  • Time Factors
  • Transcription Factors / biosynthesis
  • Transcription Factors / genetics*
  • Zebrafish / embryology*
  • Zebrafish Proteins*


  • T-Box Domain Proteins
  • TBX15 protein, mouse
  • Tbx18 protein, mouse
  • Transcription Factors
  • Zebrafish Proteins
  • tbx15 protein, zebrafish
  • tbx18 protein, zebrafish