Expression of high in normal-1 (HIN-1) and uteroglobin related protein-1 (UGRP-1) in adult and developing tissues

Mech Dev. 2002 Jun;114(1-2):201-4. doi: 10.1016/s0925-4773(02)00056-4.


We analyzed the expression of high in normal-1 (HIN-1), a putative breast tumor suppressor gene, and uteroglobin related protein-1 (UGRP-1), a homologue of HIN-1, in adult and developing mouse tissues. Highest HIN-1 and UGRP-1 expression is detected in the lung, while lower level HIN-1 expression is also detected in the stomach, heart, small intestine, uterine and mammary glands. The expression of both genes was detected only at E17.5-18.5 and the HIN-1 messenger RNA was localized to the epithelia of the trachea, bronchi, and uterine glands. The expression of HIN-1 is up-regulated during retinoic acid induced differentiation of bronchial epithelial cells. We also identified two putative Drosophila HIN-1 homologues. The expression of HIN-1 is restricted to terminally differentiated airway epithelial cells in vivo and in vitro implicating HIN-1 in the acquisition or maintenance of terminally differentiated epithelial phenotype.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Blotting, Northern
  • Bronchi / cytology
  • Carrier Proteins*
  • Cell Differentiation
  • Cytokines / biosynthesis*
  • Epithelial Cells / cytology
  • Gene Expression*
  • Genes, Tumor Suppressor
  • Lung / embryology*
  • Lung / metabolism*
  • Mice
  • Molecular Sequence Data
  • Phenotype
  • Phylogeny
  • Reverse Transcriptase Polymerase Chain Reaction
  • Secretoglobins
  • Sequence Homology, Amino Acid
  • Time Factors
  • Tissue Distribution
  • Transcription Factors / biosynthesis*
  • Tretinoin / pharmacology
  • Tumor Suppressor Proteins*
  • Up-Regulation
  • Uteroglobin


  • Carrier Proteins
  • Cytokines
  • SCGB3A1 protein, human
  • SCGB3A2 protein, human
  • Secretoglobins
  • Transcription Factors
  • Tumor Suppressor Proteins
  • Tretinoin
  • Uteroglobin