Radiosensitivity in Fanconi's anemia patients

Blanche P Alter

doi:10.1016/s0167-8140(01)00474-1

Radiosensitivity in Fanconi's anemia patients

Radiother Oncol. 2002 Mar;62(3):345-7. doi: 10.1016/s0167-8140(01)00474-1.

Author

Blanche P Alter¹

Affiliation

¹ Clinical Genetics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, 6120 Executive Boulevard, EPS 7020, Rockville, MD 20852, USA.

PMID: 12175566
DOI: 10.1016/s0167-8140(01)00474-1

Abstract

The risks of radiation therapy in patients with Fanconi's anemia who have cancer are not clear. Possible toxicity was reported in six of 14 patients: 1/1 with vaginal cancer, 4/10 with head and neck or esophageal cancer, and 1/3 with oral cancer following bone marrow transplant.

MeSH terms

Adolescent
Adult
Child
Esophageal Neoplasms / complications
Esophageal Neoplasms / radiotherapy*
Fanconi Anemia / complications*
Female
Head and Neck Neoplasms / complications
Head and Neck Neoplasms / radiotherapy*
Humans
Male
Precancerous Conditions / diagnosis
Radiation Tolerance*
Radiotherapy / adverse effects*
Risk Factors
Treatment Outcome
Vulvar Neoplasms / complications
Vulvar Neoplasms / radiotherapy*