Control of cell survival by IGF signaling pathways

Growth Horm IGF Res. 2002 Aug;12(4):193-7. doi: 10.1016/s1096-6374(02)00017-5.


The insulin-like growth factor system efficiently signals to cells to grow, differentiate, and survive. One central player in the prevention of cell death is the IGF-I receptor. Transduction of signals through this receptor leads to multiple series of intracellular phosphorylation events and the activation of several signaling pathways. Mechanisms of IGF system signaling that prevent cell death continue to be identified, suggesting that cells have alternative ways to avert death signals in addition to primary protective pathways. This review describes current knowledge of the mechanisms utilized by the IGF system to promote cell survival.

Publication types

  • Review

MeSH terms

  • Animals
  • Apoptosis / physiology*
  • Calcium Signaling
  • Cell Survival / physiology
  • Humans
  • Insulin-Like Growth Factor I / metabolism
  • Insulin-Like Growth Factor II / metabolism
  • Mitogen-Activated Protein Kinases / metabolism
  • Protein-Serine-Threonine Kinases*
  • Proto-Oncogene Proteins / metabolism
  • Proto-Oncogene Proteins c-akt
  • Receptor, IGF Type 1 / chemistry
  • Receptor, IGF Type 1 / metabolism*
  • Signal Transduction
  • Somatomedins / metabolism*


  • Proto-Oncogene Proteins
  • Somatomedins
  • Insulin-Like Growth Factor I
  • Insulin-Like Growth Factor II
  • Receptor, IGF Type 1
  • Protein-Serine-Threonine Kinases
  • Proto-Oncogene Proteins c-akt
  • Mitogen-Activated Protein Kinases