Mitotic exit: the Cdc14 double cross

Curr Biol. 2002 Jul 23;12(14):R482-84. doi: 10.1016/s0960-9822(02)00963-6.


The release of Cdc14 from the nucleolus occurs in two waves in early and late anaphase, controlled by the FEAR and MEN pathways, respectively. Two new papers report the localisation at the spindle pole body of the Cdc14 released in early anaphase and, surprisingly, show that the two pulses of released Cdc14 have opposite effects on MEN activation.

Publication types

  • Review

MeSH terms

  • Anaphase
  • Cell Cycle Proteins / physiology*
  • Fungal Proteins / metabolism
  • Fungal Proteins / physiology
  • Mitosis / physiology*
  • Phosphorylation
  • Protein Tyrosine Phosphatases*
  • Saccharomyces cerevisiae / cytology
  • Saccharomyces cerevisiae Proteins*


  • CDC14 protein, S cerevisiae
  • Cell Cycle Proteins
  • Fungal Proteins
  • Saccharomyces cerevisiae Proteins
  • Protein Tyrosine Phosphatases