Casein kinase 1: a Wnt'er of disconnect

Curr Biol. 2002 Jul 23;12(14):R499-R501. doi: 10.1016/s0960-9822(02)00969-7.

Abstract

Phosphorylation of beta-catenin, a central downstream component of the Wnt pathway, by glycogen synthase kinase 3 is essential for its targeted degradation by the proteosome. New studies show that casein kinase 1 primes beta-catenin for subsequent phophorylation by glycogen synthase kinase 3.

Publication types

  • Review

MeSH terms

  • Amino Acid Sequence
  • Casein Kinases
  • Cytoskeletal Proteins / metabolism
  • Molecular Sequence Data
  • Phosphorylation
  • Protein Kinases / chemistry
  • Protein Kinases / metabolism*
  • Proto-Oncogene Proteins / metabolism*
  • Signal Transduction
  • Trans-Activators / metabolism
  • Wnt Proteins
  • Zebrafish Proteins*
  • beta Catenin

Substances

  • Cytoskeletal Proteins
  • Proto-Oncogene Proteins
  • Trans-Activators
  • Wnt Proteins
  • Zebrafish Proteins
  • beta Catenin
  • Protein Kinases
  • Casein Kinases