Hox Genes: it's all a matter of context

Curr Biol. 2002 Aug 6;12(15):R514-6. doi: 10.1016/s0960-9822(02)01025-4.


Recent studies provide compelling new evidence that Hox gene effects depend on fine-structure spatial and temporal information. Further, in a specific cell type, only one or a few downstream genes may mediate Hox morphogenetic functions. If this is generally true, it will have important implications for how Hox regulatory networks operate and evolve.

MeSH terms

  • Animals
  • Drosophila / embryology
  • Drosophila / growth & development
  • Embryo, Nonmammalian / physiology
  • Genes, Homeobox*
  • Morphogenesis / genetics