The effect of plasma caeruloplasmin levels on the sensitivity for activated protein C

Br J Haematol. 2002 Sep;118(3):843-6. doi: 10.1046/j.1365-2141.2002.03715.x.

Abstract

The effect of caeruloplasmin levels on the sensitivity for activated protein C (APC), measured by a clotting assay based on the activated partial thromboplastin time, was investigated in a large group of healthy individuals without factor V Leiden. A modest inverse association between caeruloplasmin and normalized APC sensitivity ratio was found (regression coefficient beta = -0.33 x 10-2; 95% confidence interval, -0.42 x 10-2 to -0.24 x 10-2). After adjustment for sex and oral contraceptive use, this association weakened (beta = -0.19 x 10-2; 95% CI: -0.34 x 10-2 to -0.05 x 10-2). After additional adjustment for factor VIII levels, which are known to influence the assay, the effect of caeruloplasmin on APC sensitivity completely disappeared.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Activated Protein C Resistance / blood*
  • Adolescent
  • Adult
  • Aged
  • Case-Control Studies
  • Ceruloplasmin / analysis*
  • Contraceptives, Oral, Hormonal / pharmacology
  • Factor VIII / analysis
  • Female
  • Humans
  • Male
  • Middle Aged
  • Partial Thromboplastin Time
  • Postmenopause / blood
  • Premenopause / blood
  • Protein C / metabolism
  • Reference Values

Substances

  • Contraceptives, Oral, Hormonal
  • Protein C
  • Factor VIII
  • Ceruloplasmin