Synthesis of 1-(2-hydroxy-3-methoxypropyl)uracils and their activity against L1210 and macrophage raw 264.7 cells

Alicja Copik; Jerzy Suwinski; Krzysztof Walczak; Joanna Bronikowska; Zenon Czuba; Wojciech Król

doi:10.1081/ncn-120006831

Synthesis of 1-(2-hydroxy-3-methoxypropyl)uracils and their activity against L1210 and macrophage raw 264.7 cells

Nucleosides Nucleotides Nucleic Acids. 2002 Apr-May;21(4-5):377-83. doi: 10.1081/ncn-120006831.

Authors

Alicja Copik¹, Jerzy Suwinski, Krzysztof Walczak, Joanna Bronikowska, Zenon Czuba, Wojciech Król

Affiliation

¹ Institute of Organic Chemistry and Technology, Silesian University of Technology, Krzywoustego, Poland.

PMID: 12182349
DOI: 10.1081/ncn-120006831

Abstract

The title compounds were obtained from appropriate 5-substituted uracil derivatives and 1,2-oxy-3-methoxypropane in the presence of sodium hydride. Under similar conditions 5-iodouracil gave 2-methoxymethyl-2,3-dihydro-oxazolo[3,2-c]pyrimidine-5,7-dione as a result of intramolecular cine type nucleophilic substitution. Cytotoxicity of 1-(2-hydroxy-3-methoxypropyl)-5-substituted uracil derivatives against L1210 and macrophage RAW 264.7 cells in vitro was examined.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Cell Line
Cell Survival
Coloring Agents / pharmacology
Drug Screening Assays, Antitumor
Leukemia L1210 / drug therapy*
Macrophages / drug effects*
Magnetic Resonance Spectroscopy
Mice
Models, Chemical
Tetrazolium Salts / pharmacology
Thiazoles / pharmacology
Tumor Cells, Cultured
Uracil / chemical synthesis*
Uracil / pharmacology*

Substances

Coloring Agents
Tetrazolium Salts
Thiazoles
Uracil
thiazolyl blue