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. 2002 Aug 22;4(17):2965-7.
doi: 10.1021/ol026378e.

Short Total Synthesis of 8,10-di-O-methylbergenin


Short Total Synthesis of 8,10-di-O-methylbergenin

Holger Herzner et al. Org Lett. .


[reaction: see text] A short, high-yielding synthesis of the C-glucoside 8,10-di-O-methylbergenin is reported. Key elements of the synthesis are a stereoselective installation of a beta-C-aryl linkage, a palladium(0)-catalyzed aryl carbonylation, and a regioselective lactonization reaction. This pathway should allow access to a host of bergenin analogues.

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