Quaternary salts of E2020 analogues as acetylcholinesterase inhibitors for the reversal of neuromuscular block

Bioorg Med Chem Lett. 2002 Sep 16;12(18):2565-8. doi: 10.1016/s0960-894x(02)00482-1.

Abstract

A series benzylpiperidinium and benzylpyridinium quaternary salts have been synthesised and tested for inhibition of acetylcholinesterase and reversal of neuromuscular block induced by vecuronium. Several potent reversal agents have been identified and their haemodynamic effects measured.

MeSH terms

  • Acetylcholinesterase / drug effects*
  • Cholinesterase Inhibitors / chemistry
  • Cholinesterase Inhibitors / pharmacology*
  • Donepezil
  • Indans / chemistry
  • Indans / pharmacology*
  • Neuromuscular Nondepolarizing Agents / antagonists & inhibitors*
  • Piperidines / chemistry
  • Piperidines / pharmacology*
  • Vecuronium Bromide / antagonists & inhibitors*

Substances

  • Cholinesterase Inhibitors
  • Indans
  • Neuromuscular Nondepolarizing Agents
  • Piperidines
  • Vecuronium Bromide
  • Donepezil
  • Acetylcholinesterase