FTY720: Targeting G-protein-coupled Receptors for Sphingosine 1-phosphate in Transplantation and Autoimmunity

Curr Opin Immunol. 2002 Oct;14(5):569-75. doi: 10.1016/s0952-7915(02)00374-6.

Abstract

The novel immunomodulator FTY720 is remarkably effective in models of transplantation and autoimmunity. Recent data show that phosphorylated FTY720 is an agonist at four sphingosine 1-phosphate receptors. Stimulation of sphingosine 1-phosphate receptors leads to sequestration of lymphocytes in secondary lymphatic tissues and thus away from inflammatory lesions and graft sites.

Publication types

  • Review

MeSH terms

  • Animals
  • Autoimmune Diseases / drug therapy*
  • Bone Marrow Transplantation / immunology
  • Clinical Trials as Topic
  • Fingolimod Hydrochloride
  • Humans
  • Immunosuppressive Agents / therapeutic use*
  • Islets of Langerhans Transplantation / immunology
  • Lymph Nodes / immunology
  • Peyer's Patches / immunology
  • Propylene Glycols / pharmacology
  • Propylene Glycols / therapeutic use*
  • Receptors, Cell Surface / drug effects*
  • Receptors, G-Protein-Coupled*
  • Receptors, Lysophospholipid
  • Sphingosine / analogs & derivatives

Substances

  • Immunosuppressive Agents
  • Propylene Glycols
  • Receptors, Cell Surface
  • Receptors, G-Protein-Coupled
  • Receptors, Lysophospholipid
  • Fingolimod Hydrochloride
  • Sphingosine