Phospholipase D in hormonal and stress signaling

Curr Opin Plant Biol. 2002 Oct;5(5):408-14. doi: 10.1016/s1369-5266(02)00283-2.


Phospholipase D (PLD) is a family of diverse enzymes that are differentially regulated by Ca(2+), polyphosphoinositides, free fatty acids, G-proteins, N-acylethanolamines, and membrane lipid environments. Two new types of PLDs were identified in the past year: one is activated by oleic acid and the other requires no cation for activity. The oleate-stimulated PLD is associated with the plasma membrane and binds to microtubules. The Ca(2+)-independent PLD contains a PX and a PH domain, but not the Ca(2+)/phospholipid-binding C2 domain found in most plant PLDs. The mechanism by which Ca(2+), phosphoinositides, and G proteins regulate certain PLDs is better understood. PLDs and their product phosphatidic acid are involved in various stress responses, including water deficits, salts, wounding, and elicitation. Increasing evidence supports a role of PLD in the abscisic acid signaling cascades.

Publication types

  • Research Support, U.S. Gov't, Non-P.H.S.
  • Review

MeSH terms

  • Calcium / metabolism
  • Desiccation
  • Microtubules / metabolism
  • Multigene Family
  • Phospholipase D / biosynthesis
  • Phospholipase D / chemistry
  • Phospholipase D / genetics
  • Phospholipase D / metabolism*
  • Plant Diseases*
  • Plant Growth Regulators / pharmacology*
  • Plants / drug effects*
  • Plants / enzymology*
  • Plants / genetics
  • Signal Transduction* / drug effects


  • Plant Growth Regulators
  • Phospholipase D
  • Calcium